Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | ESR1 | P03372 | 11/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 11/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4080457 | 0.92 | LTA4H (0.64) | LTA4HPTGS2NPSR1KDM4EPOLB | |
| SCHEMBL1640980 | 0.89 | LTA4H (0.68) | LTA4HPTGS2NPSR1KDM4EPOLB | |
| SCHEMBL4084094 | 0.88 | LTA4H (0.66) | LTA4HPTGS2NPSR1KDM4EPOLB | |
| SCHEMBL4085732 | 0.88 | LTA4H (0.66) | LTA4HPTGS2NPSR1KDM4EPOLB | |
| SCHEMBL4090273 | 0.81 | ATM (0.68) | NPSR1KDM4EHRH3 | |
| SCHEMBL8780108 | 0.81 | ATM (0.59) | LTA4HPTGS2NPSR1KDM4EPOLB | |
| SCHEMBL5442329 | 0.78 | TSHR (0.66) | LTA4HKDM4EHRH3 | |
| SCHEMBL11151279 | 0.77 | HRH3 (0.81) | LTA4HHRH3 | |
| SCHEMBL30186207 | 0.77 | HRH3 (0.81) | LTA4HHRH3 | |
| SCHEMBL2475993 | 0.76 | ESR1 (0.75) | LTA4HPTGS2KDM4EESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692128-A1 | INDAZOLE COMPOUNDS AND METHODS OF USE THEREOF AS PROTEIN KINASE INHIBITORS | Signal Pharmaceuticals LLC (US) | 2006-08-23 | — | — | EP | disclosed |
| WO-2005051942-A1 | INDAZOLE COMPOUNDS AND METHODS OF USE THEREOF AS PROTEIN KINASE INHIBITORS | SIGNAL PHARMACEUTICALS, LLC (US) | 2005-06-09 | — | — | WO | disclosed |