Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 15/20 | 0.48 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.40 |
| ▸ | PDE4A | P27815 | 5/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5357303 | 0.93 | PDE4B (0.51) | PDE4BAGTR2PDE4APDE4CPDE4D | |
| SCHEMBL5357925 | 0.93 | PDE4B (0.47) | PDE4BAGTR2PDE4APDE4CPDE4D | |
| SCHEMBL5790094 | 0.93 | PDE4B (0.47) | PDE4BAGTR2PDE4APDE4CPDE4D | |
| SCHEMBL5756458 | 0.92 | PDE4B (0.51) | PDE4BAGTR2PDE4APDE4CPDE4D | |
| SCHEMBL5359900 | 0.92 | PDE4B (0.48) | PDE4BAGTR2PDE4APDE4CPDE4D | |
| SCHEMBL5355097 | 0.89 | PDE4B (0.46) | PDE4BAGTR2PDE4APDE4CPDE4D | |
| SCHEMBL5755292 | 0.87 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4DPDE7A | |
| SCHEMBL5355796 | 0.86 | PDE4B (0.54) | PDE4BAGTR2PDE4APDE4CPDE4D | |
| SCHEMBL5759093 | 0.86 | PDE4B (0.50) | PDE4BAGTR2PDE4APDE4CPDE4D | |
| SCHEMBL5757628 | 0.86 | PDE4B (0.49) | PDE4BPDE4APDE4CPDE4DPDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242400-B1 | PYRROLIDINE DERIVATIVES AS CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | ICOS CORP (US) | 2006-05-03 | — | — | EP | claimed |