Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 16/20 | 0.51 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 5/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.39 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.37 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5759093 | 0.94 | PDE4B (0.50) | PDE4BAGTR2PDE4APDE4CPDE4D | |
| SCHEMBL5355796 | 0.94 | PDE4B (0.54) | PDE4BAGTR2PDE4APDE4CPDE4D | |
| SCHEMBL5355052 | 0.93 | PDE4B (0.49) | PDE4BAGTR2PDE4APDE4CPDE4D | |
| SCHEMBL5791891 | 0.93 | PDE4B (0.49) | PDE4BAGTR2PDE4APDE4CPDE4D | |
| SCHEMBL5350761 | 0.92 | PDE4B (0.51) | PDE4BAGTR2PDE4APDE4CPDE4D | |
| SCHEMBL5754500 | 0.92 | PDE4B (0.48) | PDE4BAGTR2PDE4APDE4CPDE4D | |
| SCHEMBL4524186 | 0.92 | PDE4B (0.49) | PDE4BAGTR2PDE4APDE4CPDE4D | |
| SCHEMBL5350348 | 0.92 | PDE4B (0.48) | PDE4BAGTR2PDE4APDE4CPDE4D | |
| SCHEMBL5756309 | 0.92 | PDE4B (0.48) | PDE4BAGTR2PDE4APDE4CPDE4D | |
| SCHEMBL5355394 | 0.92 | PDE4B (0.48) | PDE4BAGTR2PDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242400-B1 | PYRROLIDINE DERIVATIVES AS CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | ICOS CORP (US) | 2006-05-03 | — | — | EP | claimed |