Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 10/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5754962 | 1.00 | GRM5 (0.58) | GRM5KCNH2ALDH1A1MEN1KMT2A | |
| SCHEMBL2895291 | 0.88 | GRM5 (0.73) | GRM5KCNH2ALDH1A1MEN1KMT2A | |
| SCHEMBL2895294 | 0.88 | GRM5 (0.73) | GRM5KCNH2ALDH1A1MEN1KMT2A | |
| SCHEMBL2895780 | 0.88 | GRM5 (0.73) | GRM5KCNH2ALDH1A1MEN1KMT2A | |
| SCHEMBL2895459 | 0.79 | GRM5 (0.57) | GRM5KCNH2ALDH1A1MEN1KMT2A | |
| SCHEMBL2891488 | 0.79 | GRM5 (0.69) | GRM5KCNH2ALDH1A1MEN1KMT2A | |
| SCHEMBL5482911 | 0.79 | GRM5 (0.71) | GRM5KCNH2MAPT | |
| SCHEMBL2895056 | 0.79 | GRM5 (0.71) | GRM5KCNH2MAPT | |
| SCHEMBL4167366 | 0.79 | GRM5 (0.71) | GRM5KCNH2PKM | |
| SCHEMBL2889471 | 0.77 | ALDH1A1 (0.48) | GRM5KCNH2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716125-A1 | TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS | AstraZeneca AB (SE) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005080356-A1 | TETRAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONITS | ASTRAZENECA AB (SE) | 2005-09-01 | — | — | WO | disclosed |