Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | MYC | P01106 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3350408 | 0.77 | SMPD3 (0.46) | PDPK1CHEK2HDAC2MYCALDH1A1 | |
| SCHEMBL27636147 | 0.74 | PDPK1 (0.53) | PDPK1KDM4EHDAC2ALDH1A1CYP2A6 | |
| 2-Phenylthiazole SCHEMBL28287735 | 0.73 | PDPK1 (0.78) | PDPK1CHEK2HDAC2MYCGAA | |
| SCHEMBL995828 | 0.72 | CSNK1A1 (0.50) | PDPK1KDM4ECHEK2HDAC2ALDH1A1 | |
| SCHEMBL30517722 | 0.72 | CSNK1A1 (0.50) | PDPK1KDM4ECHEK2HDAC2ALDH1A1 | |
| SCHEMBL5755327 | 0.71 | RAB9A (0.42) | PDPK1KDM4ECHEK2HDAC2MYC | |
| SCHEMBL3347230 | 0.71 | CHEK2 (0.41) | PDPK1CHEK2HDAC2MYCALDH1A1 | |
| Hydrochloric Acid SCHEMBL30810223 | 0.71 | CSNK1A1 (0.49) | PDPK1KDM4ECHEK2HDAC2ALDH1A1 | |
| 2-Phenylthiazole SCHEMBL5968560 | 0.71 | PDPK1 (0.68) | PDPK1CHEK2HDAC2MYCALDH1A1 | |
| SCHEMBL30810276 | 0.70 | PARP1 (0.45) | PDPK1KDM4ECHEK2HDAC2MYC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713484-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005070891-A2 | COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2005-08-04 | — | — | WO | disclosed |