Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | CDH1 | P12830 | 1/20 | 0.34 |
| ▸ | APC | P25054 | 1/20 | 0.34 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.34 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.34 |
| ▸ | KCNK3 | O14649 | 4/20 | 0.34 |
| ▸ | KCNK9 | Q9NPC2 | 4/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.33 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.33 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4680852 | 0.90 | CNR1 (0.44) | CNR1CDH1APCCTNNB1TCF7L2 | |
| SCHEMBL4683446 | 0.77 | TARBP2 (0.50) | CNR1GAADHODHNPC1RAB9A | |
| SCHEMBL4681021 | 0.76 | CNR1 (0.57) | CNR1CDH1APCCTNNB1TCF7L2 | |
| SCHEMBL4677223 | 0.74 | CNR1 (0.44) | CNR1CDH1APCCTNNB1TCF7L2 | |
| SCHEMBL4676636 | 0.71 | CNR1 (0.50) | CNR1CDH1APCCTNNB1TCF7L2 | |
| SCHEMBL4681287 | 0.71 | CNR1 (0.53) | CNR1CYP2C9 | |
| SCHEMBL4681469 | 0.71 | CDH1 (0.48) | CNR1CDH1APCCTNNB1TCF7L2 | |
| SCHEMBL4676483 | 0.70 | CNR1 (0.46) | CNR1CDH1APCCTNNB1TCF7L2 | |
| SCHEMBL4677774 | 0.70 | CNR1 (0.46) | CNR1CDH1APCCTNNB1TCF7L2 | |
| SCHEMBL27634889 | 0.69 | NR1H2 (0.39) | CNR1CDH1APCCTNNB1TCF7L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638953-A1 | 3-SUBSTITUTED 5,6-DIARYL-PYRAZINE-2-CARBOXAMIDE AND -2-SULFONAMIDE DERIVATIVES AS CB1 MODULATORS | AstraZeneca AB (SE) | 2006-03-29 | — | — | EP | disclosed |
| WO-2004111034-A1 | 3-SUBSTITUTED 5,6-DIARYL-PYRAZINE-2-CARBOXAMIDE AND -2-SULFONAMIDE DERIVATIVES AS CB1 MODULATORS | ASTRAZENECA AB (SE) | 2004-12-23 | — | — | WO | disclosed |