Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | KIF11 | P52732 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5754687 | 0.95 | KIF11 (0.39) | PDE10ACYP3A4EGFRKIF11MEN1 | |
| SCHEMBL5756600 | 0.94 | KIF11 (0.41) | CYP3A4EGFRKIF11TDP1ALDH1A1 | |
| SCHEMBL5755201 | 0.91 | KIF11 (0.40) | CYP3A4EGFRKIF11TDP1ALDH1A1 | |
| SCHEMBL5756160 | 0.91 | KIF11 (0.43) | CYP3A4EGFRKIF11TDP1ALDH1A1 | |
| SCHEMBL5753980 | 0.89 | KIF11 (0.39) | CYP3A4EGFRKIF11TDP1ALDH1A1 | |
| SCHEMBL5752111 | 0.89 | KIF11 (0.40) | CYP3A4EGFRKIF11TDP1ALDH1A1 | |
| SCHEMBL5754591 | 0.89 | KIF11 (0.38) | CYP3A4KIF11TDP1ALDH1A1POLB | |
| SCHEMBL5754399 | 0.89 | KIF11 (0.40) | CYP3A4EGFRKIF11TDP1ALDH1A1 | |
| SCHEMBL5753650 | 0.87 | KIF11 (0.46) | CYP3A4EGFRKIF11TDP1ALDH1A1 | |
| SCHEMBL5754211 | 0.87 | KMT2A (0.39) | CYP3A4EGFRKIF11KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1553931-A4 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS INC (US) | 2006-08-30 | — | — | EP | disclosed |
| EP-1553931-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | Cytokinetics, Inc. (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2003097053-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS | CYTOKINETICS, INC. (US) | 2003-11-27 | — | — | WO | disclosed |