Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 6/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.71 |
| ▸ | CACNA1F | O60840 | 5/20 | 0.49 |
| ▸ | CACNA1D | Q01668 | 5/20 | 0.49 |
| ▸ | CACNA1S | Q13698 | 5/20 | 0.49 |
| ▸ | CACNA1C | Q13936 | 5/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5477332 | 0.88 | ELANE (0.78) | ELANECYP3A4CYP2C9MAPTNPSR1 | |
| SCHEMBL5477336 | 0.88 | ELANE (0.78) | ELANECYP3A4CYP2C9MAPTNPSR1 | |
| SCHEMBL14520819 | 0.83 | ELANE (1.00) | ELANECYP3A4CYP2C9CYP2C19 | |
| SCHEMBL8344218 | 0.80 | MAPT (0.69) | ELANECYP3A4CYP2C9CACNA1FCACNA1D | |
| SCHEMBL13378063 | 0.78 | ELANE (0.91) | ELANECYP3A4CYP2C9 | |
| SCHEMBL5478484 | 0.76 | ELANE (0.88) | ELANECYP3A4CYP2C9CYP2C19 | |
| SCHEMBL5473081 | 0.75 | ELANE (0.79) | ELANECYP3A4CYP2C9MAPT | |
| SCHEMBL8344141 | 0.75 | ELANE (0.85) | ELANECYP3A4CYP2C9CACNA1FCACNA1D | |
| SCHEMBL8342078 | 0.75 | ELANE (0.85) | ELANECYP3A4CYP2C9CACNA1FCACNA1D | |
| SCHEMBL8344775 | 0.74 | ELANE (0.82) | ELANECYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7199136-B2 | 1,4-dihydro-1,4-diphenylpyridine derivatives | BAYER HEALTHCARE AG (DE) | 2007-04-03 | — | — | US | disclosed |
| US-7199136-B2 | 1,4-dihydro-1,4-diphenylpyridine derivatives | BAYER HEALTHCARE AG (DE) | 2007-04-03 | — | — | US | disclosed |
| EP-1458682-B1 | 1,4-DIHYDRO-1,4-DIPHENYLPYRIDINE DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2006-08-30 | — | — | EP | disclosed |