Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 19/20 | 0.88 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.88 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.88 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14520819 | 0.94 | ELANE (1.00) | ELANECYP2C9CYP3A4CYP2C8CYP2C19 | |
| SCHEMBL5202512 | 0.91 | ELANE (1.00) | ELANECYP2C9CYP3A4 | |
| SCHEMBL13378063 | 0.89 | ELANE (0.91) | ELANECYP2C9CYP3A4 | |
| SCHEMBL5483009 | 0.87 | ELANE (0.74) | ELANECYP2C9CYP3A4CYP2C8CYP2C19 | |
| SCHEMBL2885094 | 0.86 | ELANE (0.92) | ELANECYP2C9CYP3A4 | |
| SCHEMBL8342078 | 0.85 | ELANE (0.85) | ELANECYP2C9CYP3A4 | |
| SCHEMBL8344141 | 0.85 | ELANE (0.85) | ELANECYP2C9CYP3A4 | |
| SCHEMBL5755443 | 0.84 | ELANE (0.88) | ELANECYP2C9CYP3A4 | |
| SCHEMBL2879286 | 0.84 | ELANE (0.87) | ELANECYP2C9CYP3A4 | |
| SCHEMBL8340908 | 0.84 | ELANE (0.82) | ELANECYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7199136-B2 | 1,4-dihydro-1,4-diphenylpyridine derivatives | BAYER HEALTHCARE AG (DE) | 2007-04-03 | — | — | US | disclosed |
| US-7199136-B2 | 1,4-dihydro-1,4-diphenylpyridine derivatives | BAYER HEALTHCARE AG (DE) | 2007-04-03 | — | — | US | disclosed |
| US-7199136-B2 | 1,4-dihydro-1,4-diphenylpyridine derivatives | BAYER HEALTHCARE AG (DE) | 2007-04-03 | — | — | US | disclosed |
| EP-1458682-B1 | 1,4-DIHYDRO-1,4-DIPHENYLPYRIDINE DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2006-08-30 | — | — | EP | disclosed |
| US-20050165014-A1 | Antiinflammatory agents, neutrophil elastase inhibitors; chronic obstructive pulmonary diseases | BAYER HEALTHCARE AG | 2005-07-28 | — | — | US | disclosed |
| EP-1458682-A1 | 1,4-DIHYDRO-1,4-DIPHENYLPYRIDINE DERIVATIVES | Bayer HealthCare AG (DE) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003053930-A1 | 1,4-DIHYDRO-1,4-DIPHENYLPYRIDINE DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2003-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050165014-A1 | Antiinflammatory agents, neutrophil elastase inhibitors; chronic obstructive pulmonary diseases | SERPINB1, ELANE, MPO | ELANE 2/4885CYP2C9 3202/4885CYP3A4 1315/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.