Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 7/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MPO | P05164 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5760697 | 0.84 | KIF11 (0.83) | KIF11CYP2C19MAP1LC3BCYP3A4KCNH2 | |
| Ck0106023 SCHEMBL12393608 | 0.82 | KIF11 (1.00) | KIF11CYP2C19MAP1LC3BCYP3A4KCNH2 | |
| SCHEMBL1882393 | 0.81 | KIF11 (0.65) | KIF11CYP2C19MAP1LC3BCYP3A4KCNH2 | |
| SCHEMBL1885255 | 0.81 | KIF11 (0.64) | KIF11CYP2C19MAP1LC3BCYP3A4KCNH2 | |
| SCHEMBL12386697 | 0.80 | KIF11 (0.79) | KIF11CYP2C19MAP1LC3BCYP3A4KCNH2 | |
| SCHEMBL12386717 | 0.79 | KIF11 (0.78) | KIF11CYP2C19MAP1LC3BCYP3A4KCNH2 | |
| SCHEMBL1892039 | 0.79 | KIF11 (0.78) | KIF11CYP2C19MAP1LC3BCYP3A4KCNH2 | |
| SCHEMBL14154542 | 0.79 | KIF11 (0.91) | KIF11CYP2C19MAP1LC3BCYP3A4KCNH2 | |
| SCHEMBL1886208 | 0.78 | KIF11 (0.61) | KIF11CYP2C19MAP1LC3BCYP3A4KCNH2 | |
| SCHEMBL5758646 | 0.76 | KIF11 (0.72) | KIF11CYP2C19MAP1LC3BCYP3A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689724-A1 | QUINAZOLINONE COMPOUNDS AS ANTICANCER AGENTS | Chiron Corporation (US) | 2006-08-16 | — | — | EP | claimed |
| WO-2005051922-A1 | QUINAZOLINONE COMPOUNDS AS ANTICANCER AGENTS | CHIRON CORPORATION (US) | 2005-06-09 | — | — | WO | claimed |