Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL699752 | 0.98 | ALDH1A1 (0.46) | ATMALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL28773135 | 0.84 | ATM (0.42) | ATMALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL701798 | 0.82 | GAA (0.40) | GAACYP4F2CYP4A11 | |
| SCHEMBL4959108 | 0.82 | ATM (0.43) | ATMALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL803099 | 0.80 | MEN1 (0.52) | ATMALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL4654905 | 0.80 | MEN1 (0.43) | ATMALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL23080297 | 0.78 | MEN1 (0.55) | ATMALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL20121989 | 0.78 | MEN1 (0.55) | ATMALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL8487327 | 0.78 | ATM (0.48) | ATMALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL8487332 | 0.78 | ATM (0.48) | ATMALDH1A1L3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242400-B1 | PYRROLIDINE DERIVATIVES AS CYCLIC AMP-SPECIFIC PHOSPHODIESTERASE INHIBITORS | ICOS CORP (US) | 2006-05-03 | — | — | EP | disclosed |