Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.39 |
| ▸ | S100A4 | P26447 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29551165 | 0.81 | TDP1 (0.41) | TDP1LMNAMAPTHTTNPSR1 | |
| SCHEMBL13681603 | 0.75 | HTR1A (0.41) | NPSR1HTR1ADRD2ALDH1A1 | |
| SCHEMBL14867215 | 0.74 | ASAH1 (0.42) | TDP1LMNAMAPTNPSR1KDM4E | |
| SCHEMBL5543874 | 0.73 | JAK2 (0.48) | LMNANPSR1KDM4ETSHRHTR1A | |
| SCHEMBL14034640 | 0.73 | HTR1A (0.40) | LMNAHTTNPSR1KDM4ETSHR | |
| SCHEMBL5542528 | 0.73 | HTR1A (0.42) | LMNAHTTKDM4ETSHRHTR1A | |
| SCHEMBL7978985 | 0.73 | HTT (0.44) | MAPTHTTKDM4EGAAMAOA | |
| SCHEMBL1200356 | 0.72 | TDP1 (0.50) | TDP1LMNAMAPTHTTNPSR1 | |
| SCHEMBL23754700 | 0.72 | GAA (0.47) | TDP1MAPTHTTGAAGPR35 | |
| SCHEMBL21893887 | 0.70 | HTR1A (0.38) | LMNAHTTNPSR1KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889889-B1 | PIPERAZINE AND PIPERIDINE COMPOUNDS | DUPHAR INT RES (NL) | 2006-09-20 | — | — | EP | disclosed |
| US-6225312-B1 | TREATING A CNS DISORDER SUCH AS SCHIZOPHRENIA | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 2001-05-01 | — | — | US | disclosed |
| US-6214829-B1 | NERVOUS SYSTEM, PSYCHOLOGICAL DISORDERS | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 2001-04-10 | — | — | US | disclosed |
| EP-0900792-A1 | Piperazine and piperidine derivatives as 5-HT1 receptor agonists | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1999-03-10 | — | — | EP | disclosed |
| EP-0889889-A1 | PIPERAZINE AND PIPERIDINE COMPOUNDS | DUPHAR INTERNATIONAL RESEARCH B.V (NL) | 1999-01-13 | — | — | EP | disclosed |
| WO-1997036893-A1 | PIPERAZINE AND PIPERIDINE COMPOUNDS | DUPHAR INTERNATIONAL RESEARCH B.V. (NL) | 1997-10-09 | — | — | WO | disclosed |