Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 13/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.47 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6213700 | 0.88 | MCL1 (0.48) | ARMCL1CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL5860408 | 0.86 | GAA (0.46) | ARCYP1A2KDM4EMEN1ALDH1A1 | |
| SCHEMBL5761235 | 0.86 | AR (0.46) | ARMEN1HPGDKMT2ANPSR1 | |
| SCHEMBL5761750 | 0.84 | KDM4E (0.46) | ARCYP1A2KDM4EMEN1ALDH1A1 | |
| SCHEMBL5762374 | 0.84 | TAAR1 (0.47) | ARCYP1A2KDM4EMEN1ALDH1A1 | |
| SCHEMBL5761962 | 0.84 | KDM4E (0.46) | ARKDM4EMEN1ALDH1A1GAA | |
| SCHEMBL5758484 | 0.83 | MCL1 (0.44) | ARMCL1CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL5760140 | 0.83 | MCL1 (0.47) | ARMCL1CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL6096993 | 0.83 | KDM4E (0.48) | ARMCL1CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL5762392 | 0.82 | MAPT (0.44) | ARCYP1A1CYP1A2CYP1B1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7098340-B2 | Quinoline/chromene derivatives as androgen antagonist | WARNER LAMBERT COMPANY LLC (US) | 2006-08-29 | — | — | US | disclosed |
| US-7057048-B2 | Androgen receptor antagonists | WARNER LAMBERT COMPANY LLC (US) | 2006-06-06 | — | — | US | disclosed |
| EP-1633732-A1 | BENZYL SULFONAMIDE DERIVATIVES AS ANDROGEN RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 2006-03-15 | — | — | EP | disclosed |
| EP-1587509-A2 | ANDROGEN RECEPTOR ANTAGONISTS | Warner-Lambert Company LLC (US) | 2005-10-26 | — | — | EP | disclosed |
| US-20050137228-A1 | Benzyl sulfonamide derivatives | DU DANIEL Y (US) | 2005-06-23 | — | — | US | disclosed |
| US-20050085466-A1 | Androgen receptor antagonists | DU DANIEL Y (US) | 2005-04-21 | — | — | US | disclosed |
| WO-2004101544-A1 | BENZYL SULFONAMIDE DERIVATIVES AS ANDROGEN RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY LLC (US) | 2004-11-25 | — | — | WO | disclosed |
| WO-2004065539-A2 | ANDROGEN RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY LLC (US) | 2004-08-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050085466-A1 | Androgen receptor antagonists | AR, NR5A1, ESRRB | AR 1/4885MCL1 4676/4885CYP1A1 370/4885 |
| US-20050137228-A1 | Benzyl sulfonamide derivatives | AR, SHBG, BRDT | AR 1/4885MCL1 4501/4885CYP1A1 385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.