Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 3/20 | 0.56 |
| ▸ | CHRM3 | P20309 | 7/20 | 0.46 |
| ▸ | POLR1A | O95602 | 1/20 | 0.45 |
| ▸ | ACKR3 | P25106 | 3/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.44 |
| ▸ | EED | O75530 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6219146 | 0.91 | ELANE (0.49) | ELANECHRM3POLR1AACKR3CACNA1B | |
| SCHEMBL5756864 | 0.85 | EGLN1 (0.47) | ELANECHRM3POLR1AACKR3CACNA1B | |
| SCHEMBL5754488 | 0.84 | ELANE (0.56) | ELANE | |
| SCHEMBL5755837 | 0.84 | ELANE (0.56) | ELANE | |
| SCHEMBL5759549 | 0.84 | ELANE (0.57) | ELANENOTUM | |
| SCHEMBL5758317 | 0.83 | ELANE (0.59) | ELANENOTUM | |
| SCHEMBL5758471 | 0.83 | ELANE (0.51) | ELANE | |
| SCHEMBL5759229 | 0.82 | ELANE (0.57) | ELANE | |
| SCHEMBL5757603 | 0.82 | ELANE (0.57) | ELANE | |
| SCHEMBL5757093 | 0.81 | ELANE (0.55) | ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562902-B1 | 2-PYRIDONE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE | ASTRAZENECA AB (SE) | 2006-05-03 | — | — | EP | disclosed |
| US-20060035938-A1 | 2-Pyridone derivatives as inhibitors of neutrophile elastase | ASRAZENECA AB (SE) | 2006-02-16 | — | — | US | disclosed |
| CN-1711243-A | 2-pyridone derivatives as inhibitors of neutrophil elastase | ASTRAZENECA AB (SE) | 2005-12-21 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060035938-A1 | 2-Pyridone derivatives as inhibitors of neutrophile elastase | SERPINB1, ELANE, SERPINE1 | ELANE 2/4885CHRM3 584/4885POLR1A 743/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.