SCHEMBL5757441

SCHEMBL5757441

CC(C)(C)OC(=O)NC(CBr)Cc1ccc(Cl)cc1

nearest known ligand 0.53

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.53
PPARG P37231 1/20 0.49
PPARA Q07869 1/20 0.49
GAA P10253 1/20 0.48
CTSS P25774 6/20 0.46
CTSK P43235 6/20 0.46
CACNA1B Q00975 1/20 0.45
APP P05067 2/20 0.44
AAK1 Q2M2I8 1/20 0.43
ALDH1A1 P00352 1/20 0.43
MAPT P10636 1/20 0.43
MME P08473 1/20 0.43
ACE P12821 1/20 0.43
CTSL P07711 2/20 0.43
TRPA1 O75762 1/20 0.43
CTSB P07858 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31750709 0.88 ATM (0.54) ATMPPARGPPARAGAACTSS
SCHEMBL18589398 0.88 ATM (0.54) ATMPPARGPPARAGAACTSS
SCHEMBL7019352 0.88 ATM (0.54) ATMPPARGPPARAGAACTSS
SCHEMBL5755466 0.86 ATM (0.53) ATMCTSSCTSKAPPACE
SCHEMBL18589373 0.86 ATM (0.53) ATMPPARGPPARAGAACTSS
SCHEMBL18607994 0.86 ATM (0.53) ATMPPARGPPARAGAACTSS
SCHEMBL8330079 0.86 ATM (0.70) ATMCTSSCTSKAPPACE
SCHEMBL5755877 0.86 ATM (0.70) ATMCTSSCTSKAPPACE
SCHEMBL5757675 0.86 ATM (0.47) ATMPPARGPPARACTSSCTSK
SCHEMBL740780 0.85 MME (0.56) ATMPPARGPPARAGAACTSS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7078537-B2 Phenylalkyl diamine and amide analogs SK CORPORATION (KR) 2006-07-18 US disclosed
EP-1401821-A4 NOVEL PHENYLALKYL DIAMINE AND AMIDE ANALOGS SK CORP (KR) 2006-05-31 EP disclosed
EP-1401821-A1 NOVEL PHENYLALKYL DIAMINE AND AMIDE ANALOGS SK Corporation (KR) 2004-03-31 EP disclosed
US-20030105079-A1 Novel phenylalkyl diamine and amide analogs SK BIOPHARMACEUTICALS CO., LTD. (KR) 2003-06-05 US disclosed
WO-2002100848-A1 NOVEL PHENYLALKYL DIAMINE AND AMIDE ANALOGS SK CORPORATION (KR) 2002-12-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030105079-A1 Novel phenylalkyl diamine and amide analogs SIGMAR1, TAAR1, OPRL1 ATM 3190/4885PPARG 718/4885PPARA 500/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.