Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 15/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5755076 | 0.86 | PDE4B (0.44) | EPHX2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5759370 | 0.85 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5761415 | 0.84 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5756332 | 0.80 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5755717 | 0.76 | PDE4B (0.44) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8204723 | 0.74 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5758859 | 0.73 | PDE4B (0.41) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3606680 | 0.73 | MEN1 (0.54) | EPHX2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5823060 | 0.71 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5757544 | 0.71 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1631568-A1 | PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceuticals Corporation (US) | 2006-03-08 | — | — | EP | disclosed |
| WO-2004094411-A1 | PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2004-11-04 | — | — | WO | disclosed |