Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 10/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5755717 | 0.91 | PDE4B (0.44) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL5755076 | 0.86 | PDE4B (0.44) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL5759793 | 0.84 | PDE4A (0.41) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL5759164 | 0.84 | PDE4B (0.43) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL5756380 | 0.82 | PDE4B (0.41) | PDE4APDE4BS1PR1S1PR3PDE4D | |
| SCHEMBL5758859 | 0.82 | PDE4B (0.41) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL5758807 | 0.79 | PDE4B (0.42) | PDE4APDE4BS1PR1S1PR3PDE4D | |
| SCHEMBL5756557 | 0.78 | DHFR (0.33) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL5759401 | 0.78 | PDE4B (0.43) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL5755003 | 0.76 | PDE4B (0.42) | PDE4APDE4BPDE4DPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1631568-A1 | PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceuticals Corporation (US) | 2006-03-08 | — | — | EP | disclosed |
| WO-2004094411-A1 | PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2004-11-04 | — | — | WO | disclosed |