Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 20/20 | 0.72 |
| ▸ | MMP1 | P03956 | 13/20 | 0.72 |
| ▸ | MMP3 | P08254 | 2/20 | 0.59 |
| ▸ | MMP9 | P14780 | 2/20 | 0.59 |
| ▸ | MMP13 | P45452 | 4/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5760561 | 1.00 | ADAM17 (0.72) | ADAM17MMP1MMP3MMP9MMP13 | |
| SCHEMBL5758235 | 0.90 | ADAM17 (0.61) | ADAM17MMP1MMP3MMP13 | |
| SCHEMBL5760266 | 0.90 | ADAM17 (0.61) | ADAM17MMP1MMP3MMP13 | |
| SCHEMBL5759840 | 0.85 | ADAM17 (0.73) | ADAM17MMP1MMP3MMP9MMP13 | |
| SCHEMBL5761185 | 0.85 | ADAM17 (0.73) | ADAM17MMP1MMP3MMP9MMP13 | |
| SCHEMBL5759375 | 0.84 | ADAM17 (1.00) | ADAM17MMP1MMP3MMP9MMP13 | |
| SCHEMBL5757873 | 0.84 | ADAM17 (1.00) | ADAM17MMP1MMP3MMP9MMP13 | |
| SCHEMBL5759234 | 0.84 | ADAM17 (1.00) | ADAM17MMP1MMP3MMP9MMP13 | |
| SCHEMBL5757129 | 0.81 | ADAM17 (0.81) | ADAM17MMP1MMP3MMP9MMP13 | |
| Hydroxyamine SCHEMBL8521428 | 0.80 | ADAM17 (0.78) | ADAM17MMP1MMP3MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104403-B1 | HYDROXY PIPECOLATE HYDROXAMIC ACID DERIVATIVES AS MMP INHIBITORS | PFIZER PROD INC (US) | 2006-05-10 | — | — | EP | claimed |