Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 15/20 | 0.85 |
| ▸ | GSK3B | P49841 | 14/20 | 0.85 |
| ▸ | PRKCB | P05771 | 14/20 | 0.85 |
| ▸ | PRKCG | P05129 | 12/20 | 0.85 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.85 |
| ▸ | PRKCD | Q05655 | 6/20 | 0.85 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.85 |
| ▸ | IDH1 | O75874 | 2/20 | 0.49 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.46 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | PRKACA | P17612 | 1/20 | 0.45 |
| ▸ | PRKACG | P22612 | 1/20 | 0.45 |
| ▸ | PRKACB | P22694 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5754128 | 0.94 | PRKCA (0.85) | PRKCAGSK3BPRKCBPRKCGKCNH2 | |
| SCHEMBL13013272 | 0.92 | GSK3B (1.00) | PRKCAGSK3BPRKCBPRKCGKCNH2 | |
| SCHEMBL3771437 | 0.87 | PRKCA (0.84) | PRKCAGSK3BPRKCBPRKCGKCNH2 | |
| SCHEMBL13013368 | 0.86 | GSK3B (0.88) | PRKCAGSK3BPRKCBPRKCGKCNH2 | |
| SCHEMBL5757325 | 0.85 | GSK3B (0.83) | PRKCAGSK3BPRKCBPRKCGKCNH2 | |
| SCHEMBL3774763 | 0.85 | PRKCA (0.85) | PRKCAGSK3BPRKCBPRKCGKCNH2 | |
| SCHEMBL5814373 | 0.84 | PRKCA (1.00) | PRKCAGSK3BPRKCBPRKCGKCNH2 | |
| SCHEMBL3770811 | 0.84 | PRKCA (0.66) | PRKCAGSK3BPRKCBPRKCGKCNH2 | |
| SCHEMBL5756774 | 0.84 | GSK3B (0.88) | PRKCAGSK3BPRKCBPRKCGKCNH2 | |
| SCHEMBL4337262 | 0.84 | GSK3B (0.83) | PRKCAGSK3BPRKCBPRKCGKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362047-B1 | INDAZOLYL-SUBSTITUTED PYRROLINE COMPOUNDS AS KINASE INHIBITORS | ORTHO MCNEIL PHARM INC (US) | 2006-05-17 | — | — | EP | disclosed |