Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
| ▸ | TOP2A | P11388 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5757304 | 0.93 | TP53 (0.63) | ELANETP53MAPTLMNAMEN1 | |
| SCHEMBL5756699 | 0.92 | ELANE (0.57) | ELANETP53MAPTLMNAKMT2A | |
| SCHEMBL6212506 | 0.91 | TP53 (0.55) | ELANETP53MAPTLMNAMEN1 | |
| SCHEMBL5757167 | 0.91 | MAPT (0.53) | ELANETP53MAPTLMNAMEN1 | |
| SCHEMBL5756974 | 0.91 | ELANE (0.62) | ELANETP53MAPTLMNAMEN1 | |
| SCHEMBL6215147 | 0.90 | MAPT (0.62) | ELANETP53MAPTLMNAMEN1 | |
| SCHEMBL5756619 | 0.89 | ELANE (0.60) | ELANETP53MAPTLMNAMEN1 | |
| SCHEMBL6215751 | 0.88 | MAPT (0.51) | ELANETP53MAPTLMNASMN1; SMN2 | |
| SCHEMBL5759883 | 0.87 | ELANE (0.58) | ELANETP53MAPTLMNAMEN1 | |
| SCHEMBL5757775 | 0.87 | ELANE (0.58) | ELANETP53MAPTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562902-B1 | 2-PYRIDONE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE | ASTRAZENECA AB (SE) | 2006-05-03 | — | — | EP | disclosed |
| EP-1562902-A1 | 2-PYRIDONE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE | AstraZeneca AB (SE) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004043924-A1 | 2-PYRIDONE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE | ASTRAZENECA AB (SE) | 2004-05-27 | — | — | WO | disclosed |