Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | ELANE | P08246 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.45 |
| ▸ | KLK1 | P06870 | 2/20 | 0.45 |
| ▸ | LSS | P48449 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5755885 | 0.96 | ELANE (0.54) | MAPTLMNAELANETP53SMN1; SMN2 | |
| SCHEMBL5761223 | 0.94 | ELANE (0.55) | MAPTLMNAELANETP53ABCB1 | |
| SCHEMBL5755853 | 0.88 | ELANE (0.49) | MAPTLMNAELANETP53SMN1; SMN2 | |
| SCHEMBL5757982 | 0.88 | ELANE (0.57) | MAPTLMNAELANETP53ABCB1 | |
| SCHEMBL5756699 | 0.88 | ELANE (0.57) | MAPTLMNAELANETP53ABCB1 | |
| SCHEMBL5759628 | 0.88 | TOP2A (0.51) | MAPTELANETP53KLKB1KLK1 | |
| SCHEMBL5755817 | 0.87 | ELANE (0.52) | ELANETP53SMN1; SMN2KLKB1AKR1B1 | |
| SCHEMBL6215147 | 0.86 | MAPT (0.62) | MAPTLMNAELANETP53ABCB1 | |
| SCHEMBL5756911 | 0.86 | ELANE (0.57) | MAPTLMNAELANETP53KLKB1 | |
| SCHEMBL5759673 | 0.86 | ELANE (0.53) | LMNAELANETP53SMN1; SMN2KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562902-A1 | 2-PYRIDONE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE | AstraZeneca AB (SE) | 2005-08-17 | — | — | EP | disclosed |
| WO-2004043924-A1 | 2-PYRIDONE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE | ASTRAZENECA AB (SE) | 2004-05-27 | — | — | WO | disclosed |