SCHEMBL5758036

SCHEMBL5758036

CSc1ccc(S(=O)(=O)CC2CC[C@@H](N(C)C)CC2NC(=O)CNC(=O)c2cc(C(F)(F)F)ccc2N)cc1

nearest known ligand 0.80

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CCR2 P41597 20/20 0.80
CCR3 P51677 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2985826 1.00 CCR2 (0.80) CCR2CCR3
SCHEMBL5758031 1.00 CCR2 (0.80) CCR2CCR3
SCHEMBL2996020 0.91 CCR2 (0.82) CCR2CCR3
SCHEMBL2994183 0.91 CCR2 (0.82) CCR2CCR3
SCHEMBL2993567 0.89 CCR2 (1.00) CCR2CCR3
SCHEMBL5793729 0.88 CCR2 (1.00) CCR2CCR3
SCHEMBL5793732 0.88 CCR2 (1.00) CCR2CCR3
SCHEMBL2990813 0.88 CCR2 (1.00) CCR2CCR3
SCHEMBL2987834 0.88 CCR2 (0.79) CCR2CCR3
SCHEMBL2990162 0.86 CCR2 (0.81) CCR2CCR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1483241-A4 CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL MYERS SQUIBB CO (US) 2006-12-13 EP disclosed
EP-1483241-A2 CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Bristol-Myers Squibb Company (US) 2004-12-08 EP disclosed
WO-2003075853-A2 CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL-MYERS SQUIBB COMPANY (US) 2003-09-18 WO disclosed