Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 18/20 | 0.80 |
| ▸ | MMP1 | P03956 | 15/20 | 0.68 |
| ▸ | MMP8 | P22894 | 2/20 | 0.55 |
| ▸ | MMP3 | P08254 | 1/20 | 0.55 |
| ▸ | MMP13 | P45452 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27573313 | 1.00 | ADAM17 (0.80) | ADAM17MMP1MMP8MMP3MMP13 | |
| Hydroxyamine SCHEMBL7513406 | 0.98 | ADAM17 (0.78) | ADAM17MMP1MMP8MMP3MMP13 | |
| SCHEMBL27573308 | 0.91 | ADAM17 (0.81) | ADAM17MMP1MMP3MMP13 | |
| SCHEMBL28748328 | 0.90 | ADAM17 (0.80) | ADAM17MMP1MMP13 | |
| SCHEMBL27573328 | 0.90 | ADAM17 (0.80) | ADAM17MMP1MMP13 | |
| SCHEMBL7513418 | 0.89 | ADAM17 (0.76) | ADAM17MMP1MMP8MMP3MMP13 | |
| SCHEMBL5757799 | 0.89 | ADAM17 (1.00) | ADAM17MMP1MMP8MMP3MMP13 | |
| SCHEMBL5757960 | 0.89 | ADAM17 (1.00) | ADAM17MMP1MMP8MMP3MMP13 | |
| SCHEMBL5757113 | 0.89 | ADAM17 (1.00) | ADAM17MMP1MMP8MMP3MMP13 | |
| SCHEMBL27553230 | 0.88 | ADAM17 (0.82) | ADAM17MMP1MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104403-B1 | HYDROXY PIPECOLATE HYDROXAMIC ACID DERIVATIVES AS MMP INHIBITORS | PFIZER PROD INC (US) | 2006-05-10 | — | — | EP | claimed |