Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 19/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.68 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.68 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5755624 | 0.97 | KIF11 (0.66) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL5754219 | 0.95 | KIF11 (0.66) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL5758325 | 0.93 | KIF11 (0.62) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL5752637 | 0.93 | KIF11 (0.62) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL5752737 | 0.92 | KIF11 (0.68) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL5757138 | 0.91 | KIF11 (0.62) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL5752722 | 0.90 | KIF11 (0.63) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL4376329 | 0.90 | KIF11 (0.74) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL5755400 | 0.89 | KIF11 (0.60) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 | |
| SCHEMBL5752668 | 0.89 | KIF11 (0.70) | KIF11KCNH2MAP1LC3BCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1503993-A4 | COMPOUNDS, METHODS AND COMPOSITIONS | CYTOKINETICS INC (US) | 2006-05-03 | — | — | EP | disclosed |
| EP-1503993-A2 | COMPOUNDS, METHODS AND COMPOSITIONS | Cytokinetics, Inc. (US) | 2005-02-09 | — | — | EP | disclosed |
| WO-2003094839-A2 | PYRIMIDINONE COMPOUNDS, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2003-11-20 | — | — | WO | disclosed |