Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 10/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1544241 | 0.85 | KMT2A (0.56) | ALDH1A1SMN1; SMN2ATMKMT2ALMNA | |
| SCHEMBL1543614 | 0.83 | ALDH1A1 (0.56) | NPC1RAB9AALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL1543774 | 0.83 | SMN1; SMN2 (0.52) | NPC1RAB9AALDH1A1SMN1; SMN2ATM | |
| SCHEMBL1544430 | 0.82 | TSHR (0.41) | OPRK1ALDH1A1SMN1; SMN2ATML3MBTL1 | |
| SCHEMBL5761187 | 0.81 | MAPT (0.52) | OPRK1NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL4951627 | 0.81 | ALDH1A1 (0.47) | OPRK1ALDH1A1NPSR1POLBLMNA | |
| SCHEMBL1544291 | 0.81 | KMT2A (0.43) | NPC1RAB9AALDH1A1SMN1; SMN2ATM | |
| SCHEMBL1543588 | 0.79 | TSHR (0.47) | ALDH1A1SMN1; SMN2ATMNPSR1KMT2A | |
| SCHEMBL1544332 | 0.78 | KMT2A (0.52) | ALDH1A1SMN1; SMN2ATMNPSR1KMT2A | |
| SCHEMBL1545016 | 0.77 | KMT2A (0.51) | ALDH1A1SMN1; SMN2ATMKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1723144-A1 | ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2006-11-22 | — | — | EP | disclosed |
| WO-2006014185-A1 | ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2006-02-09 | — | — | WO | disclosed |