Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 8/20 | 0.53 |
| ▸ | RAB9A | P51151 | 9/20 | 0.51 |
| ▸ | NPC1 | O15118 | 8/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1544309 | 0.86 | KCNH2 (0.53) | GRM5RAB9ANPC1ALDH1A1KCNH2 | |
| SCHEMBL5760939 | 0.78 | GRM5 (0.53) | GRM5RAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1543652 | 0.76 | KCNH2 (0.55) | GRM5RAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1544676 | 0.75 | TP53 (0.48) | GRM5RAB9ANPC1KCNH2TP53 | |
| SCHEMBL1544620 | 0.75 | KCNH2 (0.68) | GRM5RAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1544056 | 0.74 | KCNH2 (0.51) | GRM5RAB9ANPC1MAPTKCNH2 | |
| SCHEMBL4945927 | 0.73 | RAB9A (0.48) | GRM5RAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1544356 | 0.73 | KCNH2 (0.54) | GRM5RAB9ANPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL1543822 | 0.72 | S1PR1 (0.47) | RAB9ANPC1SMN1; SMN2ALDH1A1KCNH2 | |
| SCHEMBL1544947 | 0.72 | KDM4E (0.46) | RAB9ANPC1SMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1723144-A1 | ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2006-11-22 | — | — | EP | disclosed |
| WO-2006014185-A1 | ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS | ASTRAZENECA AB (SE) | 2006-02-09 | — | — | WO | disclosed |