Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 9/20 | 0.43 |
| ▸ | PDE4A | P27815 | 10/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5755003 | 0.90 | PDE4B (0.42) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL5759164 | 0.83 | PDE4B (0.43) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL5758807 | 0.80 | PDE4B (0.42) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL5756380 | 0.79 | PDE4B (0.41) | PDE4BPDE4APDE4CPDE4DKDM4E | |
| SCHEMBL5755717 | 0.78 | PDE4B (0.44) | PDE4BPDE4APDE4CPDE4DMAPK1 | |
| SCHEMBL5757544 | 0.78 | PDE4A (0.41) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5757971 | 0.77 | PDE4B (0.39) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5755076 | 0.77 | PDE4B (0.44) | PDE4BPDE4APDE4CPDE4DHTT | |
| SCHEMBL5759793 | 0.76 | PDE4A (0.41) | PDE4BPDE4APDE4CPDE4DALDH1A1 | |
| SCHEMBL5758859 | 0.76 | PDE4B (0.41) | PDE4BPDE4APDE4CPDE4DHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1631568-A1 | PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceuticals Corporation (US) | 2006-03-08 | — | — | EP | claimed |
| WO-2004094411-A1 | PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2004-11-04 | — | — | WO | claimed |
| EP-1631568-A1 | PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceuticals Corporation (US) | 2006-03-08 | — | — | EP | disclosed |
| WO-2004094411-A1 | PYRAZOLE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2004-11-04 | — | — | WO | disclosed |