Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 2/20 | 0.44 |
| ▸ | CNR2 | P34972 | 2/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | TOP2A | P11388 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5757403 | 0.79 | CNR1 (0.64) | CNR1CNR2PDE10AALDH1A1HPGD | |
| SCHEMBL2861261 | 0.73 | HPGD (0.64) | NCEH1ALDH1A1HPGDSMN1; SMN2KMT2A | |
| SCHEMBL717950 | 0.72 | HPGD (0.63) | NCEH1ALDH1A1HPGDKDM4EKMT2A | |
| SCHEMBL20169886 | 0.71 | NCEH1 (0.56) | NCEH1HPGDSMN1; SMN2KMT2AL3MBTL1 | |
| SCHEMBL13342857 | 0.71 | SMN1; SMN2 (0.53) | NCEH1HPGDSMN1; SMN2L3MBTL1TP53 | |
| SCHEMBL5759224 | 0.70 | CNR2 (0.68) | CNR1CNR2ALDH1A1HPGDKDM4E | |
| SCHEMBL18832855 | 0.69 | PDE10A (0.73) | PDE10AALDH1A1KDM4EMAPK1 | |
| SCHEMBL2860234 | 0.68 | HPGD (0.54) | ALDH1A1HPGDSMN1; SMN2KMT2AMAPK1 | |
| SCHEMBL28838999 | 0.68 | KDM4E (0.68) | NCEH1HPGDKDM4EKMT2AL3MBTL1 | |
| SCHEMBL9660434 | 0.68 | HPGD (0.54) | NCEH1ALDH1A1HPGDKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562902-B1 | 2-PYRIDONE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE | ASTRAZENECA AB (SE) | 2006-05-03 | — | — | EP | claimed |