Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9658483 | 0.95 | PTPN1 (0.52) | HPGDLMNASMN1; SMN2NCEH1TP53 | |
| SCHEMBL9660536 | 0.91 | PTPN1 (0.53) | HPGDLMNASMN1; SMN2NCEH1TP53 | |
| SCHEMBL9659922 | 0.86 | KMT2A (0.45) | HPGDLMNASMN1; SMN2NCEH1KDM4E | |
| SCHEMBL9657625 | 0.85 | MEN1 (0.46) | HPGDLMNASMN1; SMN2NCEH1TP53 | |
| SCHEMBL9657950 | 0.84 | NCEH1 (0.45) | HPGDLMNASMN1; SMN2NCEH1 | |
| SCHEMBL9655074 | 0.83 | NPC1 (0.52) | HPGDLMNASMN1; SMN2NCEH1TP53 | |
| SCHEMBL9659913 | 0.82 | NCEH1 (0.55) | NCEH1 | |
| SCHEMBL9656111 | 0.82 | POLB (0.53) | HPGDLMNASMN1; SMN2NCEH1PTPN1 | |
| SCHEMBL9659401 | 0.82 | POLB (0.50) | HPGDLMNASMN1; SMN2NCEH1PTPN1 | |
| SCHEMBL9660610 | 0.82 | ALDH1A1 (0.53) | HPGDSMN1; SMN2KDM4EL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155132-A | Nonsteroidal antiinflammatory agents; treating psoriasis | SYNTEX (U.S.A.) INC. (US) | 1992-10-13 | — | — | US | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| US-4758587-A | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-07-19 | — | — | US | disclosed |