Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2736780 | 0.82 | CNR1 (0.57) | LMNAHTTSMN1; SMN2HRH3HPGD | |
| SCHEMBL5760050 | 0.80 | NCEH1 (0.47) | SMN1; SMN2NCEH1HPGDALDH1A1CNR1 | |
| SCHEMBL2736774 | 0.74 | CNR2 (0.54) | SMN1; SMN2EPHX1NPC1RAB9AALDH1A1 | |
| SCHEMBL717950 | 0.67 | HPGD (0.63) | LMNANCEH1HPGDNPC1RAB9A | |
| SCHEMBL2736554 | 0.67 | CNR2 (0.64) | HPGDNPC1RAB9AALDH1A1CNR1 | |
| SCHEMBL20169886 | 0.67 | NCEH1 (0.56) | SMN1; SMN2NCEH1HPGDNPC1RAB9A | |
| SCHEMBL13342857 | 0.66 | SMN1; SMN2 (0.53) | LMNAHTTSMN1; SMN2NCEH1HPGD | |
| SCHEMBL27630590 | 0.66 | HDAC3 (0.62) | SMN1; SMN2EPHX1HPGDNPC1RAB9A | |
| SCHEMBL2834010 | 0.65 | GAA (0.56) | LMNASMN1; SMN2HPGDALDH1A1KMT2A | |
| SCHEMBL27652150 | 0.65 | HDAC3 (0.60) | SMN1; SMN2EPHX1HPGDNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562902-B1 | 2-PYRIDONE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE | ASTRAZENECA AB (SE) | 2006-05-03 | — | — | EP | claimed |