Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QPCT | Q16769 | 5/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2544215 | 0.85 | CDK2 (0.46) | QPCTADRA2AADRA2CADRA1DADRA1A | |
| SCHEMBL3628524 | 0.80 | QPCT (0.80) | QPCT | |
| SCHEMBL4740274 | 0.80 | PARP1 (0.52) | QPCTADRA2AADRA2CADRA1DADRA1A | |
| SCHEMBL21646358 | 0.79 | ADRA2A (0.42) | QPCTADRA2AADRA2CADRA1DADRA1A | |
| SCHEMBL14045640 | 0.77 | IGF1R (0.46) | QPCTADRA2AADRA2CADRA1DADRA1A | |
| SCHEMBL30579943 | 0.76 | BRAF (0.47) | QPCTADRA2AADRA2CADRA1DADRA1A | |
| SCHEMBL6625328 | 0.75 | MAPT (0.47) | QPCTADRA2AADRA2CADRA1DADRA1A | |
| SCHEMBL2541307 | 0.75 | EGFR (0.43) | QPCTADRA2AADRA2CADRA1DADRA1A | |
| SCHEMBL30579941 | 0.75 | NAMPT (0.51) | QPCTADRA2AADRA2CADRA1DADRA1A | |
| Hydrochloric Acid SCHEMBL28348710 | 0.74 | EGFR (0.42) | QPCTADRA2AADRA2CADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060106225-A1 | N3 alkylated benzimidazole derivatives as MEK inhibitors | ARRAY BIOPHARMA INC. | 2006-05-18 | — | — | US | disclosed |
| EP-1482944-A4 | N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS | ARRAY BIOPHARMA INC (US) | 2006-04-19 | — | — | EP | disclosed |
| CN-1652792-A | N3 alkylated benzimidazole derivatives as MEK inhibitors | ARRAY BIOPHARMA INC (US) | 2005-08-10 | — | — | CN | disclosed |
| EP-1482944-A2 | N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS | Array Biopharma, Inc. (US) | 2004-12-08 | — | — | EP | disclosed |
| US-20030216460-A1 | N3 alkylated benzimidazole derivatives as MEK inhibitors | ARRAY BIOPHARMA, INC. | 2003-11-20 | — | — | US | disclosed |
| WO-2003077855-A2 | N3 ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS | ARRAY BIOPHARMA, INC (US) | 2003-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060106225-A1 | N3 alkylated benzimidazole derivatives as MEK inhibitors | CCNI, BRAF, CCNT1 | QPCT 3782/4885ADRA2A 2913/4885ADRA2C 2552/4885 |
| US-20030216460-A1 | N3 alkylated benzimidazole derivatives as MEK inhibitors | CCNI, BRAF, CCNT1 | QPCT 3593/4885ADRA2A 3066/4885ADRA2C 2654/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.