Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.52 |
| ▸ | MASP2 | O00187 | 5/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 5/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5763034 | 1.00 | KDM1A (0.52) | KDM1AMASP2SLC6A2F2AKR1C3 | |
| SCHEMBL5763990 | 0.81 | KDM1A (0.50) | KDM1AMASP2F2KCNH2HRH3 | |
| SCHEMBL5764621 | 0.81 | KDM1A (0.50) | KDM1AMASP2F2KCNH2HRH3 | |
| SCHEMBL5761997 | 0.81 | KDM1A (0.52) | KDM1AMASP2F2KCNH2HRH3 | |
| SCHEMBL5763039 | 0.81 | MASP2 (0.42) | MASP2F2ALDH1A1KDM4E | |
| SCHEMBL5764222 | 0.81 | KDM1A (0.52) | KDM1AMASP2F2KCNH2HRH3 | |
| SCHEMBL5764210 | 0.81 | KDM1A (0.52) | KDM1AMASP2F2KCNH2HRH3 | |
| SCHEMBL5761726 | 0.81 | MASP2 (0.42) | MASP2F2ALDH1A1KDM4E | |
| SCHEMBL5762783 | 0.75 | KDM1A (0.54) | KDM1AALDH1A1KDM4E | |
| SCHEMBL5763037 | 0.75 | KDM1A (0.54) | KDM1AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | claimed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | claimed |
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | disclosed |