Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2113176 | 0.98 | EDNRA (0.34) | EDNRAKDM4EALDH1A1ALOX15HSD17B10 | |
| SCHEMBL5762009 | 0.94 | EDNRA (0.33) | EDNRA | |
| SCHEMBL19782813 | 0.78 | CA12 (0.35) | KDM4EALDH1A1ALOX15HSD17B10CYP19A1 | |
| SCHEMBL1751661 | 0.76 | KMT2A (0.39) | ALDH1A1ALOX15HSD17B10 | |
| SCHEMBL567737 | 0.73 | CYP19A1 (0.33) | CYP19A1 | |
| SCHEMBL2067485 | 0.72 | PIK3C3 (0.45) | EDNRAHSD17B10CYP19A1 | |
| SCHEMBL3132631 | 0.72 | KDM4E (0.43) | KDM4EALDH1A1ALOX15HSD17B10 | |
| SCHEMBL629463 | 0.71 | ALDH1A1 (0.48) | EDNRAKDM4EALDH1A1ALOX15HSD17B10 | |
| SCHEMBL28940994 | 0.69 | KMT2A (0.35) | KDM4EALDH1A1ALOX15HSD17B10 | |
| SCHEMBL28940996 | 0.69 | HDAC1 (0.40) | KDM4EALDH1A1ALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611091-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004089885-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-10-21 | — | — | WO | disclosed |