Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 6/20 | 0.68 |
| ▸ | EGFR | P00533 | 2/20 | 0.68 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.64 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.64 |
| ▸ | NOD2 | Q9HC29 | 3/20 | 0.64 |
| ▸ | CDK4 | P11802 | 6/20 | 0.62 |
| ▸ | CCND1 | P24385 | 6/20 | 0.62 |
| ▸ | CCND2 | P30279 | 6/20 | 0.62 |
| ▸ | CCND3 | P30281 | 6/20 | 0.62 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.62 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.62 |
| ▸ | CDK1 | P06493 | 3/20 | 0.62 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.62 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.62 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.62 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.62 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.62 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.62 |
| ▸ | CDK2 | P24941 | 3/20 | 0.62 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5764524 | 0.90 | FGFR1 (0.72) | FGFR1EGFRRIPK2ACVR1NOD2 | |
| SCHEMBL5762208 | 0.90 | FGFR1 (0.75) | FGFR1EGFRRIPK2ACVR1NOD2 | |
| SCHEMBL5764948 | 0.88 | CDK4 (0.56) | FGFR1EGFRRIPK2ACVR1NOD2 | |
| SCHEMBL5761780 | 0.86 | FGFR1 (0.70) | FGFR1EGFRRIPK2ACVR1NOD2 | |
| SCHEMBL5763095 | 0.86 | FGFR1 (0.70) | FGFR1EGFRRIPK2ACVR1NOD2 | |
| SCHEMBL5763272 | 0.84 | RIPK2 (0.49) | FGFR1EGFRRIPK2ACVR1NOD2 | |
| SCHEMBL5762040 | 0.84 | FGFR1 (0.66) | FGFR1EGFRRIPK2ACVR1NOD2 | |
| SCHEMBL5262288 | 0.82 | CDK4 (0.70) | FGFR1EGFRRIPK2ACVR1NOD2 | |
| SCHEMBL5762083 | 0.81 | FGFR1 (1.00) | FGFR1EGFRRIPK2ACVR1NOD2 | |
| SCHEMBL14040742 | 0.81 | RIPK2 (0.79) | FGFR1EGFRRIPK2ACVR1NOD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0823908-B1 | PYRIDO[2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2006-11-02 | — | — | EP | claimed |
| WO-2005105097-A2 | PYRIDOPYRIMIDINES FOR TREATING INFLAMMATORY AND OTHER DISEASES | GPC BIOTECH AG (DE) | 2005-11-10 | — | — | WO | claimed |
| EP-0823908-A1 | PYRIDO 2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1998-02-18 | — | — | EP | claimed |
| WO-1996034867-A1 | PYRIDO[2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1996-11-07 | — | — | WO | claimed |
| EP-0823908-B1 | PYRIDO[2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005105097-A2 | PYRIDOPYRIMIDINES FOR TREATING INFLAMMATORY AND OTHER DISEASES | GPC BIOTECH AG (DE) | 2005-11-10 | — | — | WO | disclosed |
| US-5945422-A | ANTICANCER AGENTS; ATHEROSCLEROSIS; RESTENOSIS; PSORIASIS | WARNER-LAMBERT COMPANY (US) | 1999-08-31 | — | — | US | disclosed |
| US-5733914-A | Pyrido 2, 3-d!pyrimidines for inhibiting protein tyrosine kinase mediated cellular proliferation | WARNER-LAMBERT COMPANY (US) | 1998-03-31 | — | — | US | disclosed |
| EP-0823908-A1 | PYRIDO 2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1998-02-18 | — | — | EP | disclosed |
| WO-1996034867-A1 | PYRIDO[2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1996-11-07 | — | — | WO | disclosed |