Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 4/20 | 0.51 |
| ▸ | EGFR | P00533 | 3/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | WEE1 | P30291 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16986362 | 0.82 | FGFR1 (0.69) | FGFR1EGFRWEE1SRCFGFR2 | |
| SCHEMBL2249833 | 0.75 | SRC (0.40) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL16986361 | 0.75 | FGFR1 (0.59) | FGFR1EGFRWEE1SRCFGFR2 | |
| SCHEMBL2250006 | 0.74 | SRC (0.37) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL2246053 | 0.74 | CNR1 (0.39) | FGFR1EGFRWEE1SRCFGFR2 | |
| SCHEMBL2246715 | 0.73 | FGFR1 (0.39) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL16986341 | 0.73 | FGFR1 (0.57) | FGFR1EGFRWEE1SRCFGFR2 | |
| SCHEMBL2250574 | 0.73 | WEE1 (0.42) | FGFR1WEE1SRCFGFR2FGFR4 | |
| SCHEMBL2245153 | 0.73 | SRC (0.36) | FGFR1EGFRBTKWEE1SRC | |
| SCHEMBL16287793 | 0.72 | FGFR1 (0.56) | FGFR1EGFRWEE1SRCFGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0823908-B1 | PYRIDO[2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2006-11-02 | — | — | EP | claimed |
| WO-2005105097-A2 | PYRIDOPYRIMIDINES FOR TREATING INFLAMMATORY AND OTHER DISEASES | GPC BIOTECH AG (DE) | 2005-11-10 | — | — | WO | claimed |
| EP-0823908-A1 | PYRIDO 2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1998-02-18 | — | — | EP | claimed |
| WO-1996034867-A1 | PYRIDO[2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1996-11-07 | — | — | WO | claimed |