Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.49 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 5/20 | 0.35 |
| ▸ | MASP2 | O00187 | 3/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | XIAP | P98170 | 1/20 | 0.33 |
| ▸ | BIRC3 | Q13489 | 1/20 | 0.33 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5762190 | 1.00 | KDM1A (0.49) | KDM1ASCN3AF2MASP2USP2 | |
| SCHEMBL5761997 | 0.83 | KDM1A (0.52) | KDM1AF2MASP2KCNH2HRH3 | |
| SCHEMBL5764222 | 0.83 | KDM1A (0.52) | KDM1AF2MASP2KCNH2HRH3 | |
| SCHEMBL5764210 | 0.83 | KDM1A (0.52) | KDM1AF2MASP2KCNH2HRH3 | |
| SCHEMBL5764621 | 0.81 | KDM1A (0.50) | KDM1ASCN3AF2MASP2KCNH2 | |
| SCHEMBL5763990 | 0.81 | KDM1A (0.50) | KDM1ASCN3AF2MASP2KCNH2 | |
| SCHEMBL5762197 | 0.81 | XIAP (0.47) | XIAPBIRC3BIRC2 | |
| SCHEMBL5762909 | 0.81 | XIAP (0.47) | XIAPBIRC3BIRC2 | |
| SCHEMBL5761133 | 0.80 | KDM1A (0.54) | KDM1ASCN3AKCNH2HRH3 | |
| SCHEMBL5762404 | 0.80 | KDM1A (0.54) | KDM1ASCN3AKCNH2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | claimed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | claimed |
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | disclosed |