Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XIAP | P98170 | 12/20 | 0.47 |
| ▸ | CTSK | P43235 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.36 |
| ▸ | BIRC3 | Q13489 | 1/20 | 0.36 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5762197 | 1.00 | XIAP (0.47) | XIAPCTSKALDH1A1PSMB5BIRC3 | |
| SCHEMBL3243559 | 0.83 | ALDH1A1 (0.42) | ALDH1A1KDM4E | |
| SCHEMBL3823350 | 0.83 | ALDH1A1 (0.42) | ALDH1A1KDM4E | |
| SCHEMBL5764228 | 0.83 | XIAP (0.39) | XIAPALDH1A1 | |
| SCHEMBL5762000 | 0.83 | XIAP (0.39) | XIAPALDH1A1 | |
| SCHEMBL5764216 | 0.83 | XIAP (0.39) | XIAPALDH1A1 | |
| SCHEMBL5763995 | 0.81 | NAAA (0.46) | XIAPALDH1A1 | |
| SCHEMBL5764623 | 0.81 | NAAA (0.46) | XIAPALDH1A1 | |
| SCHEMBL5762190 | 0.81 | KDM1A (0.49) | XIAPBIRC3BIRC2 | |
| SCHEMBL5762906 | 0.81 | KDM1A (0.49) | XIAPBIRC3BIRC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | claimed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | claimed |
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | disclosed |