Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 4/20 | 0.56 |
| ▸ | F2 | P00734 | 4/20 | 0.39 |
| ▸ | MASP2 | O00187 | 8/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5763512 | 1.00 | KDM1A (0.56) | KDM1AF2MASP2HDAC2F2RL1 | |
| SCHEMBL5761075 | 1.00 | KDM1A (0.56) | KDM1AF2MASP2HDAC2F2RL1 | |
| SCHEMBL5763400 | 0.81 | KDM1A (0.39) | KDM1AF2RL1 | |
| SCHEMBL5761078 | 0.81 | KDM1A (0.39) | KDM1AF2RL1 | |
| SCHEMBL5763516 | 0.81 | KDM1A (0.39) | KDM1AF2RL1 | |
| SCHEMBL5763037 | 0.80 | KDM1A (0.54) | KDM1AF2RL1 | |
| SCHEMBL5762783 | 0.80 | KDM1A (0.54) | KDM1AF2RL1 | |
| SCHEMBL5763990 | 0.80 | KDM1A (0.50) | KDM1AF2MASP2 | |
| SCHEMBL5764621 | 0.80 | KDM1A (0.50) | KDM1AF2MASP2 | |
| SCHEMBL5792639 | 0.79 | KDM1A (0.56) | KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | claimed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | claimed |
| EP-1636196-A1 | NOVEL LACTAMS AND USES THEREOF | AstraZeneca AB (SE) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004080983-A1 | NOVEL LACTAMS AND USES THEREOF | ASTRAZENECA AB (SE) | 2004-09-23 | — | — | WO | disclosed |