SCHEMBL5763433

SCHEMBL5763433

CCN=C(NO)c1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATM Q13315 1/20 0.42
HDAC1 Q13547 3/20 0.40
IDO1 P14902 2/20 0.40
HSD17B10 Q99714 2/20 0.40
ALOX15 P16050 2/20 0.40
HDAC6 Q9UBN7 2/20 0.40
HDAC3 O15379 1/20 0.40
CA12 O43570 1/20 0.40
CA1 P00915 1/20 0.40
CA9 Q16790 1/20 0.40
HDAC7 Q8WUI4 1/20 0.40
HDAC2 Q92769 1/20 0.40
HDAC8 Q9BY41 1/20 0.40
NCOR2 Q9Y618 1/20 0.40
CYP3A4 P08684 2/20 0.40
CYP2C19 P33261 1/20 0.40
CYP1A2 P05177 1/20 0.37
CYP2D6 P10635 1/20 0.37
KDM4E B2RXH2 3/20 0.37
MAPT P10636 3/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20306025 0.85 ATM (0.43) ATMHSD17B10ALOX15CYP3A4CYP2C19
SCHEMBL3064720 0.82 ATM (0.41) ATMHSD17B10ALOX15CYP3A4CYP2C19
SCHEMBL3064719 0.82 ATM (0.41) ATMHSD17B10ALOX15CYP3A4CYP2C19
SCHEMBL975934 0.80 NAAA (0.42) HDAC1HDAC6CES1MEN1KMT2A
SCHEMBL19040657 0.73 GLA (0.40) ATMHSD17B10ALOX15CYP3A4CYP2C19
SCHEMBL134570 0.73 IDO1 (0.46) HDAC1IDO1HSD17B10ALOX15HDAC6
SCHEMBL3942966 0.73 IDO1 (0.46) HDAC1IDO1HSD17B10ALOX15HDAC6
SCHEMBL6377003 0.73 ATM (0.48) ATMHSD17B10ALOX15CYP3A4CYP1A2
SCHEMBL6745833 0.71 IDO1 (0.44) HDAC1IDO1HSD17B10ALOX15HDAC6
SCHEMBL3560645 0.71 IDO1 (0.44) HDAC1IDO1HSD17B10ALOX15HDAC6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1723144-A1 ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS AstraZeneca AB (SE) 2006-11-22 EP disclosed
WO-2006014185-A1 ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS ASTRAZENECA AB (SE) 2006-02-09 WO disclosed