Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | CSF1R | P07333 | 2/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8305598 | 0.95 | PDE4B (0.54) | PDE4BDRD2HTR2ADRD3CSF1R | |
| SCHEMBL5462967 | 0.89 | PDE4B (0.50) | PDE4BDRD2HTR2ADRD3TYK2 | |
| SCHEMBL4923595 | 0.87 | PDE4B (0.53) | PDE4BKCNH2CNR2CSF1RATM | |
| SCHEMBL5457430 | 0.85 | PDE4B (0.55) | PDE4BCNR2CSF1R | |
| SCHEMBL5763422 | 0.85 | PDE4B (0.57) | PDE4BCSF1R | |
| SCHEMBL31020770 | 0.83 | PDE4B (0.61) | PDE4BKCNH2CSF1RATM | |
| SCHEMBL5765982 | 0.82 | PDE4B (0.52) | PDE4BKCNH2CSF1RATM | |
| SCHEMBL5399007 | 0.81 | PDE4B (0.53) | PDE4BCSF1R | |
| SCHEMBL5404792 | 0.81 | PDE4B (0.51) | PDE4BCSF1RATR | |
| SCHEMBL5405232 | 0.81 | PDE4B (0.54) | PDE4BCSF1RJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673345-A1 | DERIVATIVES OF 3-AMINOCARBONYLQUINOLINE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES AND INTERMEDIATES FOR THEIR PREPARATION | GLAXO GROUP LIMITED (GB) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005030725-A1 | DERIVATIVES OF 3-AMINOCARBONYLQUINOLINE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES AND INTERMEDIATES FOR THEIR PREPARATION | GLAXO GROUP LIMITED (GB) | 2005-04-07 | — | — | WO | disclosed |