Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 4/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | EED | O75530 | 1/20 | 0.34 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.34 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.34 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.34 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | BRD2 | P25440 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5763422 | 0.83 | PDE4B (0.57) | PDE4BMTNR1BCSF1RTHRBEED | |
| SCHEMBL5763692 | 0.82 | PDE4B (0.54) | PDE4BCSF1RKCNH2ATM | |
| SCHEMBL8305598 | 0.82 | PDE4B (0.54) | PDE4BMTNR1BCSF1R | |
| SCHEMBL5457430 | 0.82 | PDE4B (0.55) | PDE4BCSF1RCYP3A4CYP2C9 | |
| SCHEMBL5405232 | 0.81 | PDE4B (0.54) | PDE4BMTNR1BCSF1RCYP3A4CYP2C9 | |
| SCHEMBL31020770 | 0.81 | PDE4B (0.61) | PDE4BMTNR1BCSF1RTHRBKCNH2 | |
| SCHEMBL5399007 | 0.80 | PDE4B (0.53) | PDE4BMTNR1BCSF1RBRD4 | |
| SCHEMBL2505851 | 0.79 | PDE4B (0.59) | PDE4BMTNR1BCSF1RTHRB | |
| SCHEMBL5413089 | 0.79 | PDE4B (0.49) | PDE4BCSF1RCYP3A4CYP2C9KCNH2 | |
| SCHEMBL1275589 | 0.79 | PDE4B (0.75) | PDE4BCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673345-A1 | DERIVATIVES OF 3-AMINOCARBONYLQUINOLINE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES AND INTERMEDIATES FOR THEIR PREPARATION | GLAXO GROUP LIMITED (GB) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005030725-A1 | DERIVATIVES OF 3-AMINOCARBONYLQUINOLINE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESSES AND INTERMEDIATES FOR THEIR PREPARATION | GLAXO GROUP LIMITED (GB) | 2005-04-07 | — | — | WO | disclosed |