Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 9/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.58 |
| ▸ | EED | O75530 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 5/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5762010 | 0.83 | SLC6A2 (0.58) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL26387507 | 0.82 | SLC6A2 (0.62) | SLC6A2SLC6A4SLC6A3DRD2DRD3 | |
| SCHEMBL5760877 | 0.81 | SLC6A2 (0.63) | SLC6A2SLC6A4SLC6A3HTR2C | |
| SCHEMBL4486743 | 0.81 | EED (0.52) | SLC6A2SLC6A4SLC6A3EEDHTR2C | |
| SCHEMBL4498808 | 0.78 | SLC6A2 (0.67) | SLC6A2SLC6A4SLC6A3DRD2 | |
| SCHEMBL6183614 | 0.77 | SLC6A2 (0.72) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3127165 | 0.77 | SLC6A2 (0.55) | SLC6A2SLC6A4SLC6A3EED | |
| SCHEMBL5763178 | 0.77 | SLC6A2 (0.59) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL5761304 | 0.76 | SLC6A2 (0.54) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4491890 | 0.75 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638934-A1 | 3-AMINOPYRROLIDINES AS INHIBITORS OF MONOAMINE UPTAKE | ELI LILLY AND COMPANY (US) | 2006-03-29 | — | — | EP | claimed |
| WO-2005000811-A1 | 3-AMINOPYRROLIDINES AS INHIBITORS OF MONOAMINE UPTAKE | ELI LILLY AND COMPANY (US) | 2005-01-06 | — | — | WO | claimed |
| EP-1638934-A1 | 3-AMINOPYRROLIDINES AS INHIBITORS OF MONOAMINE UPTAKE | ELI LILLY AND COMPANY (US) | 2006-03-29 | — | — | EP | disclosed |
| WO-2005000811-A1 | 3-AMINOPYRROLIDINES AS INHIBITORS OF MONOAMINE UPTAKE | ELI LILLY AND COMPANY (US) | 2005-01-06 | — | — | WO | disclosed |