Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CTSA | P10619 | 1/20 | 0.37 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5763920 | 0.87 | PTGDR2 (0.46) | PTGDR2ALDH1A1LMNAKMT2A | |
| SCHEMBL5764049 | 0.83 | BACE1 (0.54) | PTGDR2BACE1ALDH1A1ERN1SLC6A4 | |
| SCHEMBL27658681 | 0.82 | PTGDR2 (0.40) | PTGDR2ALDH1A1CTSA | |
| SCHEMBL1052379 | 0.80 | TDP1 (0.50) | ALDH1A1SLC6A3HPGDLMNASMN1; SMN2 | |
| SCHEMBL330287 | 0.79 | TSHR (0.51) | ALDH1A1PTGER1HPGDLMNASMN1; SMN2 | |
| SCHEMBL21328027 | 0.78 | TDP1 (0.49) | ALDH1A1SLC6A3HPGDLMNASMN1; SMN2 | |
| SCHEMBL21328029 | 0.78 | TDP1 (0.49) | ALDH1A1SLC6A3HPGDLMNASMN1; SMN2 | |
| SCHEMBL21328039 | 0.78 | TDP1 (0.49) | ALDH1A1SLC6A3HPGDLMNASMN1; SMN2 | |
| SCHEMBL21328025 | 0.78 | TDP1 (0.49) | ALDH1A1SLC6A3HPGDLMNASMN1; SMN2 | |
| SCHEMBL3962123 | 0.78 | TDP1 (0.49) | ALDH1A1SLC6A3HPGDLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611091-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004089885-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-10-21 | — | — | WO | disclosed |