Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.54 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.49 |
| ▸ | CFD | P00746 | 1/20 | 0.49 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.45 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAPDH | P04406 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5763924 | 0.88 | PTGDR2 (0.49) | BACE1PTGDR2CFDAMY1AALDH1A1 | |
| SCHEMBL5764044 | 0.83 | PTGDR2 (0.47) | BACE1PTGDR2AMY1AALDH1A1SLC6A4 | |
| SCHEMBL27877483 | 0.83 | SLC6A4 (0.53) | BACE1ALDH1A1KDM4EGAATSHR | |
| SCHEMBL4055219 | 0.82 | TMIGD3 (0.53) | BACE1PTGDR2CFDAMY1AALOX5 | |
| SCHEMBL1690266 | 0.81 | PTGDR2 (0.42) | BACE1PTGDR2CFDAMY1ANR1H4 | |
| SCHEMBL11338058 | 0.80 | KDM4E (0.58) | CFDAMY1ANR1H4ABCB11ALDH1A1 | |
| SCHEMBL11442668 | 0.79 | PTGDR2 (0.49) | PTGDR2ALDH1A1KDM4ERAB9ATSHR | |
| SCHEMBL13861245 | 0.79 | BACE1 (0.67) | BACE1CFDALOX5GAPDHKDM4E | |
| SCHEMBL3691064 | 0.79 | KMT2A (0.61) | CFDNR1H4ABCB11ALDH1A1KDM4E | |
| SCHEMBL134715 | 0.78 | KMT2A (0.57) | CFDNR1H4ABCB11ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611091-A1 | NOVEL COMPOUNDS | AstraZeneca AB (SE) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004089885-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2004-10-21 | — | — | WO | disclosed |