Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 9/20 | 0.65 |
| ▸ | HTR2A | P28223 | 8/20 | 0.65 |
| ▸ | HTR1A | P08908 | 7/20 | 0.65 |
| ▸ | DRD2 | P14416 | 7/20 | 0.65 |
| ▸ | HTR6 | P50406 | 7/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.65 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.65 |
| ▸ | HTR3B | O95264 | 1/20 | 0.65 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.65 |
| ▸ | PGR | P06401 | 1/20 | 0.65 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.65 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.65 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.65 |
| ▸ | GOT1 | P17174 | 1/20 | 0.65 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.65 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.65 |
| ▸ | DRD1 | P21728 | 1/20 | 0.65 |
| ▸ | DRD4 | P21917 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5766837 | 0.94 | HTR2A (0.73) | HTR7HTR2AHTR1ADRD2HTR6 | |
| SCHEMBL9843893 | 0.89 | HTR2A (0.68) | HTR7HTR2AHTR1ADRD2HTR6 | |
| SCHEMBL5792289 | 0.85 | HTR1A (0.90) | HTR7HTR2AHTR1ADRD2HTR6 | |
| SCHEMBL9366347 | 0.82 | HTR2A (0.85) | HTR7HTR2AHTR1ADRD2HTR6 | |
| SCHEMBL13569784 | 0.82 | HTR2A (0.68) | HTR7HTR2AHTR1ADRD2HTR6 | |
| SCHEMBL12636008 | 0.81 | HTR2A (0.80) | HTR7HTR2AHTR1ADRD2HTR6 | |
| SCHEMBL5764327 | 0.81 | HTR1A (0.67) | HTR7HTR2AHTR1ADRD2KCNH2 | |
| SCHEMBL9367357 | 0.80 | HTR2A (0.82) | HTR7HTR2AHTR1ADRD2HTR6 | |
| Ziprasidone SCHEMBL1650481 | 0.79 | HTR2A (0.96) | HTR7HTR2AHTR1ADRD2HTR6 | |
| SCHEMBL5765752 | 0.79 | HTR2A (0.55) | HTR7HTR2AHTR1ADRD2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701954-A1 | N-SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES | Warner-Lambert Company LLC (US) | 2006-09-20 | — | — | EP | disclosed |
| WO-2005066165-A1 | N-SUBSTITUTED PIPERIDINE AND PIPERAZINE DERIVATIVES | WARNER-LAMBERT COMPANY LLC (US) | 2005-07-21 | — | — | WO | disclosed |