Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.78 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.78 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.78 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.78 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.78 |
| ▸ | TSHR | P16473 | 5/20 | 0.78 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.78 |
| ▸ | USP2 | O75604 | 4/20 | 0.78 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.78 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.78 |
| ▸ | TP53 | P04637 | 2/20 | 0.78 |
| ▸ | RECQL | P46063 | 1/20 | 0.78 |
| ▸ | CCNC | P24863 | 2/20 | 0.77 |
| ▸ | CDK8 | P49336 | 2/20 | 0.77 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.77 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | HTT | P42858 | 3/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29383948 | 0.87 | CCNC (1.00) | LMNAALDH1A1CYP1A2HSD17B10MAPK1 | |
| SCHEMBL23683117 | 0.87 | PDE5A (0.65) | LMNAALDH1A1CYP1A2HSD17B10MAPK1 | |
| SCHEMBL16172718 | 0.87 | CCNC (1.00) | LMNAALDH1A1CYP1A2HSD17B10MAPK1 | |
| Hydrochloric Acid SCHEMBL31244865 | 0.86 | CCNC (0.98) | LMNAALDH1A1CYP1A2HSD17B10MAPK1 | |
| SCHEMBL19117833 | 0.82 | CCNC (0.66) | LMNAALDH1A1CYP1A2HSD17B10MAPK1 | |
| SCHEMBL17845927 | 0.81 | LMNA (1.00) | LMNAALDH1A1CYP1A2HSD17B10MAPK1 | |
| SCHEMBL7503174 | 0.80 | PDE5A (0.62) | LMNAALDH1A1CYP1A2HSD17B10MAPK1 | |
| SCHEMBL1734678 | 0.80 | LMNA (0.72) | LMNAALDH1A1CYP1A2HSD17B10MAPK1 | |
| SCHEMBL9921364 | 0.80 | LMNA (0.72) | LMNAALDH1A1CYP1A2HSD17B10MAPK1 | |
| SCHEMBL21750414 | 0.79 | CCNC (0.77) | LMNAALDH1A1CYP1A2HSD17B10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615636-A1 | BICYCLIC COMPOUNDS AS NR2B RECEPTOR ANTAGONISTS | PFIZER INC. (US) | 2006-01-18 | — | — | EP | disclosed |
| WO-2004089366-A1 | BICYCLIC COMPOUNDS AS NR2B RECEPTOR ANTAGONISTS | PFIZER JAPAN, INC. (JP) | 2004-10-21 | — | — | WO | disclosed |
| US-20040204409-A1 | Bicyclic compounds as NR2B receptor antagonists | ANDO KAZUO (JP) | 2004-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040204409-A1 | Bicyclic compounds as NR2B receptor antagonists | GRIN1, GRIN2B, GRIN2A | LMNA 3923/4885ALDH1A1 1871/4885CYP1A2 1408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.