Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 19/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 19/20 | 0.44 |
| ▸ | PDK3 | Q15120 | 19/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 19/20 | 0.44 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.37 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.37 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.37 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5764100 | 1.00 | PDK1 (0.44) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL5766316 | 1.00 | PDK1 (0.44) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL13141672 | 0.87 | CCNE2 (0.31) | — | |
| SCHEMBL7833134 | 0.84 | PDK1 (0.45) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL7829272 | 0.84 | PDK1 (0.46) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL7835701 | 0.83 | PDK1 (0.48) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL5766893 | 0.82 | CCNE2 (0.43) | — | |
| SCHEMBL3621875 | 0.82 | METAP1 (0.41) | — | |
| SCHEMBL7834669 | 0.81 | PDK1 (0.43) | PDK1PDK2PDK3PDK4ABCC9 | |
| SCHEMBL7820592 | 0.81 | PDK1 (0.43) | PDK1PDK2PDK3PDK4ABCC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0979821-B1 | TRICYCLIC COMPOUNDS | KYOWA HAKKO KOGYO KK (JP) | 2006-09-13 | — | — | EP | disclosed |
| US-6211227-B1 | SULFUR CONTAINING TRICYCLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-04-03 | — | — | US | disclosed |
| EP-0979821-A1 | TRICYCLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2000-02-16 | — | — | EP | disclosed |