Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK11 | Q15759 | 8/20 | 0.58 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.58 |
| ▸ | MAPK13 | O15264 | 5/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.31 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.30 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5763875 | 0.90 | MAPK14 (0.71) | MAPK11MAPK14MAPK13MAPK12 | |
| SCHEMBL5762518 | 0.90 | MAPK14 (0.71) | MAPK11MAPK14MAPK13MAPK12 | |
| SCHEMBL5764488 | 0.90 | MAPK14 (0.49) | MAPK11MAPK14MAPK13MAPK12RAF1 | |
| SCHEMBL5766612 | 0.89 | MAPK14 (0.57) | MAPK11MAPK14MAPK13MAPK12 | |
| SCHEMBL5764750 | 0.86 | MAPK11 (0.49) | MAPK11MAPK14MAPK13MAPK12 | |
| SCHEMBL5763268 | 0.86 | MAPK11 (0.55) | MAPK11MAPK14MAPK13MAPK12KIF11 | |
| SCHEMBL5762860 | 0.83 | MAPK11 (0.56) | MAPK11MAPK14MAPK13MAPK12RAF1 | |
| SCHEMBL5764383 | 0.82 | MAPK14 (0.50) | MAPK11MAPK14MAPK13MAPK12RAF1 | |
| SCHEMBL6219555 | 0.81 | MAPK14 (0.62) | MAPK11MAPK14RIPK3 | |
| SCHEMBL5764827 | 0.80 | MAPK14 (0.50) | MAPK11MAPK14MAPK13MAPK12RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377577-B1 | PYRROLE DERIVATES FOR TREATING CYTOKINE MEDIATED DISEASES | SANKYO CO (JP) | 2006-06-14 | — | — | EP | claimed |