Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.38 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.38 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14027328 | 0.91 | KDM4E (0.43) | CCR5KDM4EKMT2AALDH1A1MEN1 | |
| SCHEMBL4009350 | 0.91 | KDM4E (0.43) | CCR5KDM4EKMT2AALDH1A1MEN1 | |
| SCHEMBL14027327 | 0.91 | KDM4E (0.43) | CCR5KDM4EKMT2AALDH1A1MEN1 | |
| SCHEMBL14027324 | 0.90 | CCR5 (0.51) | CCR5KDM4EKMT2AALDH1A1MEN1 | |
| SCHEMBL4365822 | 0.90 | CCR5 (0.51) | CCR5KDM4EKMT2AALDH1A1MEN1 | |
| SCHEMBL4160949 | 0.89 | KDM4E (0.45) | CCR5KDM4EKMT2AALDH1A1MEN1 | |
| SCHEMBL14027220 | 0.83 | KDM4E (0.49) | CCR5KDM4EKMT2AALDH1A1MEN1 | |
| SCHEMBL14027308 | 0.79 | SPHK2 (0.44) | CCR5KDM4EKMT2AALDH1A1MEN1 | |
| SCHEMBL14027306 | 0.79 | SPHK2 (0.44) | CCR5KDM4EKMT2AALDH1A1MEN1 | |
| SCHEMBL4361737 | 0.79 | SPHK2 (0.44) | CCR5KDM4EKMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644337-A1 | MELANOCORTIN-4 RECEPTOR BINDING COMPOUNDS AND METHODS OF USE THEREOF | Gene Logic, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005121100-A1 | MELANOCORTIN-4 RECEPTOR BINDING COMPOUNDS AND METHODS OF USE THEREOF | GENE LOGIC INC. (US) | 2005-12-22 | — | — | WO | disclosed |