Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 15/20 | 0.78 |
| ▸ | EGFR | P00533 | 9/20 | 0.78 |
| ▸ | SRC | P12931 | 9/20 | 0.66 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.64 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.64 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.64 |
| ▸ | ABL1 | P00519 | 3/20 | 0.61 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.61 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.61 |
| ▸ | WEE1 | P30291 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5763301 | 0.88 | FGFR1 (1.00) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL5763919 | 0.82 | FGFR1 (1.00) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL5762061 | 0.81 | FGFR1 (1.00) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL5763017 | 0.79 | FGFR1 (1.00) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL5764642 | 0.78 | FGFR1 (1.00) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL5761199 | 0.78 | FGFR1 (1.00) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL5764474 | 0.78 | FGFR1 (1.00) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL5762069 | 0.76 | FGFR1 (1.00) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL5764908 | 0.75 | FGFR1 (1.00) | FGFR1EGFRSRCFGFR2FGFR4 | |
| SCHEMBL5762726 | 0.75 | FGFR1 (1.00) | FGFR1EGFRSRCFGFR2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0823908-B1 | PYRIDO[2,3-d]PYRIMIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2006-11-02 | — | — | EP | claimed |
| WO-2005105097-A2 | PYRIDOPYRIMIDINES FOR TREATING INFLAMMATORY AND OTHER DISEASES | GPC BIOTECH AG (DE) | 2005-11-10 | — | — | WO | claimed |